Sulfopeptide fragmentation in electron-capture and electron-transfer dissociation
نویسندگان
چکیده
منابع مشابه
Electron attachment step in electron capture dissociation (ECD) and electron transfer dissociation (ETD).
We have made use of classical dynamics trajectory simultions and ab initio electronic structure calculations to estimate the cross sections with which electrons are attached (in electron capture dissociation (ECD)) or transferred (in electron transfer dissociation (ETD)) to a model system that contained both an S-S bond that is cleaved and a -NH(3)(+) positively charged site. We used a Landau-Z...
متن کاملDistance dependence of through-bond electron transfer rates in electron-capture and electron-transfer dissociation
Ab initio electronic structure calculations on model cations containing a disulfide linkage and a protonated amine site are carried out to examine ow the rate of electron transfer from a Rydberg orbital on the amine site to the S S * orbital depends upon the distance between these two rbitals. These simulations are relevant to both electron-capture and electron-transfer dissociation mass spectr...
متن کاملProbing the mechanism of electron capture and electron transfer dissociation using tags with variable electron affinity.
Electron capture dissociation (ECD) and electron transfer dissociation (ETD) of doubly protonated electron affinity (EA)-tuned peptides were studied to further illuminate the mechanism of these processes. The model peptide FQpSEEQQQTEDELQDK, containing a phosphoserine residue, was converted to EA-tuned peptides via beta-elimination and Michael addition of various thiol compounds. These include ...
متن کاملStatistical analysis of electron transfer dissociation pairwise fragmentation patterns.
Electron transfer dissociation (ETD) is an alternative peptide dissociation method developed in recent years. Compared with the traditional collision induced dissociation (CID) b and y ion formation, ETD generates c and z ions and the backbone cleavage is believed to be less selective. We have reported previously the application of a statistical data mining strategy, K-means clustering, to disc...
متن کاملElectron capture dissociation, electron detachment dissociation and infrared multiphoton dissociation of sucrose octasulfate.
The structural analysis of sulfated carbohydrates such as glycosaminoglycans (GAGs) has been a long- standing challenge for the field of mass spectrometry. The dissociation of sulfated carbohydrates by collisionally- activated dissociation (CAD) or infrared multiphoton dissociation (IRMPD), which activate ions via vibrational excitation, typically result in few cleavages and abundant SO(3) loss...
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ژورنال
عنوان ژورنال: Journal of the American Society for Mass Spectrometry
سال: 2007
ISSN: 1044-0305,1879-1123
DOI: 10.1016/j.jasms.2007.06.002